Diagnostic value of bronchial wash, bronchial brushing, fine needle aspi- ration cytology versus combined bronchial wash and bronchial brushing in the diagnosis of primary lung carcinomas at a tertiary care hospital

نویسندگان

  • Shagufta Tahir Mufti
  • Ghadeer A. Mokhtar
چکیده

Different cytological techniques have been successfully applied for the diagnosis of primary lung cancers. Flexible fiberoptic bronchoscopy has served as a major breakthrough in respiratory cytology, as bronchial brushings, washings and fine needle aspiration have become more easy, accessible and cost effective.This study aims to determine the diagnostic value of bronchial wash (BW), bronchial brushing (BB) and fine needle aspiration (FNA) cytological samples in diagnosing primary lung carcinoma, among patients attending King Abdulaziz University Hospital,Jeddah Saudi Arabia. A retrospective analysis was performed to compare the diagnostic value of the three specimens’ types among patients with a clinical suspicion of primary lung carcinoma. All cytology specimens of bronchial washing, bronchial brushing and fine needle aspirate of lung performed for a clinical diagnosis of primary lung carcinoma, between Jan 2000Dec 2013, were identified and evaluated in comparison to their respective histological correlations. Combined BB + BW showed the best sensitivity (90.6%), specificity (75%), PPV (98%) and Global Accuracy (89.5%), when compared to any of the three techniques employed individually. In ROC curves analysis, combined BB + BW showed the highest diagnostic significance with an Area Under Curve (AUC)=.828 (p value = .030), followed by BB with an AUC=.774 (p value=.004) and FNA with an AUC = .767, (p value= .042). Combination of bronchial brush and bronchial wash complement each other and enhance the diagnostic efficacy of lung cytology for the diagnosis of primary lung carcinoma and are more superior when compared with bronchial brush, bronchial wash or FNA performed individually.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

صحت تشخیصی سیتولوژی شست و شوی برونش در تشخیص سرطان ریه

Background & Aims: Lung cancer as the most common cancer leads to 30% and 26% of deaths in men and women, respectively. Most patients with lung cancer are diagnosed in advanced stages, so their surgical procedures are not often successful. Therefore, early diagnosis has the key role in treatment and life expectancy of patients. The aim of this study was to determine sensitivity, specificit...

متن کامل

Comparison of bronchial brushing, washing and forceps biopsies in diagnosis of bronchogenic carcinoma

  Five hundred eighty patients underwent diagnostic flexible fiberoptic bronchoscopy: during June 1988 to March 1993 at the bronchoscopy center of Kerman university of medical sciences. Seventy six specimens were obtained from patients with bronchogenic carcinoma and 155 from patients with benign disease of the lung. The efficiency of brushing and washing techniques was compared with forceps b...

متن کامل

Bronchial Brushing Cytologic Finding of Primary Pulmonary Adenoid Cystic Carcinoma Misinterpretated as Small Cell Carcinoma - A Case Report with Literature Review -

An adenoid cystic carcinoma (ACC) of the lung is a malignant tumor that arises in ducts of bronchial submucosal mucous glands. ACC of the lower respiratory tract constitutes ≤0.2% of all primary pulmonary tumors. A diagnosis of ACC on cytology is uncommon even on exfoliative cytology, as well as fine needle aspiration cytology. To the best of our knowledge, this is the second case of bronchial ...

متن کامل

[Effect of different bronchial washing sequences on diagnostic yield in endoscopically visible lung cancer].

OBJECTIVE Aspiration of bronchial wash fluid is commonly used in conjunction with brushing and forceps biopsy to diagnose endoscopically visible lung cancer. However, the optimal sequence of these procedures is subject to debate. The objective of this study was to determine if the order in which bronchial washing is performed relative to bronchial brushing and forceps biopsy has any effect on t...

متن کامل

Cytohistological correlation in diagnosis of lung tumors by using fiberoptic bronchoscopy: study of 200 cases.

BACKGROUND Examination of specimens obtained through flexible fiberoptic bronchoscope is an important and often the initial diagnostic technique performed in patients with suspected malignant lung lesion. AIMS To evaluate the correlation of cytological findings of bronchial washings, bronchial brushing and imprint smear of bronchial biopsy in the diagnosis of lung tumors, with histopathology ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015